Pharmaceutical Drug Discovery and Nanotechnology

Recent advancements in pharmaceutical drug discovery and nanotechnology have significantly improved the delivery and efficacy of precision therapies. Advances in nanoparticle (NP) design now enable the overcoming of diverse biological barriers to drug delivery, including biodistribution and intracellular trafficking. These developments facilitate targeted drug delivery to specific sites within the body, enhancing the overall effectiveness of treatments and enabling personalized medicine approaches.

Pharmaceutical drug discovery has been revolutionized by the integration of nanotechnology, offering new methods for developing and delivering medications. Nanotechnology provides tools for designing drug delivery systems with improved efficacy, targeting capabilities, and reduced toxicity. Different nanostructures, such as nanobubbles, paramagnetic nanoparticles, liposomes, niosomes, dendrimers, polymeric micelles, polymeric nanoparticles, nanocapsules, solid lipid nanoparticles, and nanoemulsions, are tailored for specific therapeutic purposes. These nanostructures can be used for targeted therapy, enhanced drug solubility, and controlled drug release, addressing some of the major challenges in pharmaceutical sciences ​​.

Nanobiotechnology merges nanotechnology with biotechnology, promising groundbreaking advances in drug discovery, development, and molecular diagnostics. It utilizes nanoscale materials for diagnosis, delivery, sensory, or actuation purposes in living organisms. Nanobiotechnology aims to enhance oral and topical drug delivery, improve molecular imaging for brain tissue engineering, assist in drug uptake through the blood-brain barrier, and provide high bioavailability and effective targeting of DNA and RNA molecules to specific sites, avoiding enzymatic degradation​​.

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