Biomarkers

Although there are numerous crucial applications for biomarkers in clinical practise and product testing, most of them have not been proven to accurately predict clinical outcomes. Several of these case studies demonstrate how promising phase 2 biomarker data does not always transfer into successful product performance. Phase 2 testing of medications for disorders including AD (semagacestat), cardiac disease (aliskiren, darapladib, torcetrapib), Staph infection (V710 vaccine), and herpes infection (herpes simplex) revealed positive biomarker results (HSV-2 vaccine). In phase 3 trials, these investigational goods were not shown to be productive.


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